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. 2017 Nov 22;22(3):1743–1754. doi: 10.1111/jcmm.13455

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© 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Inhibition induced by siMYOFs is consistent with that by MMP‐2 inhibitor, SB‐3CT. A, SB‐3CT inhibited A375 cells forming VM structures in vitro (100×). Each condition was carried out with three individual replicates. B, Invasion of A375 cells was suppressed by SB‐3CT in Transwell assay (200×). C, Migration of A375 cells was affected by SB‐3CT in Wound healing assay (100×). D, The activity of MMP‐2 and MMP‐9 secreted by A375 cells treated with different concentrations of SB‐3CT was detected by Zymography assay.*P < 0.05; **P < 0.01.