Fig. 14.

Cur or SLCP reduce neuroinflammation in the striatum of 5xFAD mice. The 5xFAD mice were treated with Cur or SLCP for 2- and 5-days, sacrificed, and their brain sections were collected and immunolabeled for Iba-1 and GFAP. The number of Iba-1-IR (a, b) and GFAP-IR (a, c) labeled cells was significantly reduced (**p < 0.01) in the striatum in comparison to untreated 5xFAD mice. Significant reductions were observed after 5 days, in comparison to 2 days of treatment, on measures of both GFAP and Iba-1 labeling (b, c). Scale bar indicates 250 µm and is applicable to other images