FIG. 4.

Molecular associations of sirtuins with ARS-related targets. The figure illustrates the wide variety of ARS-related targets that have been shown to be regulated with sirtuins. Interestingly, several of the proteins appear to have common targets for SIRTs 1–7. For example, NRF2 appears to be a common target for SIRTs 1–3, 5, and 6, to mediate antioxidative genes. The large number of targets identified for SIRT1 suggests it may be more involved in ARS regulation than other sirtuins, although it may be a by-product of its popularity in research and early identification instead.