FIG. 7.

SIRT5 promotes apoptotic resistance. SIRT5 expression positively correlates with the expression of NRF2, a regulator of redox homeostatic and xenobiotic metabolism genes. SIRT5 deacetylates and promotes the nuclear translocation of FOXO3A, a transcriptional regulator of antioxidant defense genes. SIRT5 also interacts with BCL-XL, which inhibits apoptosis. Figures were produced using material from Servier Medical Art (www.servier.com). BCL-XL, B cell lymphoma-XL; FOXO3A, forkhead box O3A; NRF2, nuclear factor erythroid-2-related factor 2.