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. 2018 Mar 10;28(8):691–710. doi: 10.1089/ars.2017.7258

FIG. 4.

FIG. 4.

The mRNA distribution of sirtuins in a mouse brain reveals region-specific gene expression. Images obtained from the Allen Mouse Brain Atlas-Brain Explorer® 2 based on an ISH experiment targeting sirtuins. Gene-specific antisense probes were used to detect the mRNA distribution of the seven sirtuin members (SIRT1–7) in the brain of a 56-day-old male mouse using sagittal brain sections. The top left image represents the three-dimensional anatomical structures of the mouse brain. Original ISH sagittal images can be viewed on the Allen Brain Atlas website along with the ISH probe sequences used for each experiment. ISH, in situ hybridization.