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Pathways of cerebral ischemic protection and injury regulated by sirtuins. The figure represents the main pathways regulated by the seven sirtuin members (SIRT1–7) in the context of cerebral ischemic injuries. These pathways were shown to be modulated upon the pharmacological or genetic manipulation of sirtuins using in vitro and in vivo models of cerebral ischemia and, in turn, either promote ischemic protection against the insult or further contribute to it.
