Table 3.
Associations between urinary phthalate metabolite concentrations and serum AMH1 in multivariable linear models (n = 415)
| Metabolite | Model 14 | Model 25 |
|---|---|---|
| β (95% CI) | β (95% CI) | |
| MMP2 | ||
| 16 (< 5.18) | Ref | Ref |
| 2 (5.18–12.21) | − 0.06 (− 0.29, 0.17) | 0.03 (− 0.19, 0.24) |
| 3 (12.21–25.78) | − 0.10 (− 0.34, 0.14) | 0.05 (− 0.17, 0.27) |
| 4 (> 25.78) | 0.02 (− 0.22, 0.25) | 0.04 (− 0.18, 0.26) |
| MEP2 | ||
| 16 (< 6.02) | Ref | Ref |
| 2 (6.02–12.80) | − 0.10 (− 0.35, 0.14) | − 0.08 (− 0.30, 0.15) |
| 3 (12.80–33.98) | − 0.05 (− 0.30, 0.20) | − 0.10 (− 0.32, 0.13) |
| 4 (> 33.98) | − 0.08 (− 0.33, 0.17) | − 0.12 (− 0.34, 0.11) |
| MBP2 | ||
| 16 (< 73.85) | Ref | Ref |
| 2 (73.85–184.55) | 0.28 (0.04, 0.52) | 0.18 (−0.03, 0.40) |
| 3 (184.55–342.12) | 0.01 (− 0.24, 0.27) | − 0.08 (− 0.31, 0.16) |
| 4 (> 342.12) | 0.18 (− 0.10, 0.47) | 0.11 (− 0.15, 0.37) |
| MBzP2 | ||
| 16 (< 0.035) | Ref | Ref |
| 2 (0.035–0.102) | 0.04 (−0.20, 0.27) | 0.04 (−0.17, 0.26) |
| 3 (0.102–0.27) | −0.06 (− 0.31, 0.20) | 0.02 (− 0.21, 0.25) |
| 4 (> 0.27) | 0.12 (−0.14, 0.38) | 0.15 (−0.08, 0.38) |
| MEHP2 | ||
| 16 (< 6.95) | Ref | Ref |
| 2 (6.95–17.21) | 0.12 (−0.11, 0.35) | 0.10 (−0.11, 0.31) |
| 3 (17.21–36.01) | 0.06 (− 0.18, 0.31) | 0.01 (−0.21, 0.24) |
| 4 (> 36.01) | 0.20 (−0.05, 0.45) | 0.16 (−0.07, 0.39) |
| MEHHP2 | ||
| 16 (< 10.94) | Ref | Ref |
| 2 (10.94–19.09) | 0.08 (−0.16, 0.33) | 0.09 (−0.14, 0.31) |
| 3 (19.09–34.68) | 0.12 (−0.15, 0.39) | 0.12 (−0.13, 0.36) |
| 4 (> 34.68) | 0.24 (−0.04, 0.52) | 0.17 (−0.08, 0.43) |
| MEOHP2 | ||
| 16 (< 7.41) | Ref | Ref |
| 2 (7.41–15.34) | 0.02 (−0.22, 0.26) | −0.03 (− 0.26, 0.19) |
| 3 (15.34–27.72) | −0.03 (− 0.29, 0.22) | − 0.05 (− 0.29, 0.18) |
| 4 (> 27.72) | 0.16 (− 0.11, 0.44) | 0.05 (− 0.21, 0.30) |
| ∑DEHP2 | ||
| 16 (< 0.10) | Ref | Ref |
| 2 (0.10–0.19) | 0.14 (−0.10, 0.39) | 0.07 (−0.15, 0.29) |
| 3 (0.19–0.35) | 0.01 (−0.25, 0.26) | −0.02 (− 0.25, 0.21) |
| 4 (> 0.35) | 0.19 (−0.08, 0.46) | 0.12 (− 0.13, 0.36) |
| MOP3 | 0.16 (−0.02, 0.34) | 0.20 (0.04, 0.37) |
Statistically significant results comparing a specific category to the reference are bolded
1Serum AMH levels were natural logarithm transformed
2Phthalate metabolite concentrations were categorized into quartiles
3Dichotomous variable based on above/below limits of detection
4Model 1 was adjusted for age, BMI and creatinine
5Model 2 was adjusted for age, BMI, creatinine and PCO/PCOS diagnosis (yes or no)
6Reference category