Table 4.
Associations between urinary phthalate metabolite concentrations and serum INHB1 in multivariable linear models (n = 404)
| Metabolite | Model 14 | Model 25 |
|---|---|---|
| Percent change6 (95% CI) | Percent change6 (95% CI) | |
| MMP2 | ||
| 17 (< 5.18) | Ref | Ref |
| 2 (5.18–12.21) | −2.47 (− 17.72, 15.49) | − 0.30 (− 15.80, 17.94) |
| 3 (12.21–25.78) | −1.00 (− 16.72, 17.70) | 3.15 (− 13.24, 22.75) |
| 4 (> 25.78) | 4.71 (− 11.75, 24.23) | 5.23 (− 11.13, 24.73) |
| MEP2 | ||
| 17 (< 6.02) | Ref | Ref |
| 2 (6.02–12.80) | −4.40 (− 19.83, 14.00) | − 3.92 (− 19.27, 14.34) |
| 3 (12.80–33.98) | 3.36 (− 13.50, 23.49) | 1.82 (− 14.62, 21.41) |
| 4 (> 33.98) | 0.50 (− 16.31, 20.56) | − 0.80 (− 17.22, 18.89) |
| MBP2 | ||
| 17 (< 73.85) | Ref | Ref |
| 2 (73.85–184.55) | − 9.79 (− 24.19, 7.47) | −11.84 (− 25.84, 4.81) |
| 3 (184.55–342.12) | − 16.56 (− 30.65, 0.50) | −18.62 (− 32.23, − 2.18) |
| 4 (> 342.12) | − 14.02 (− 30.16, 5.87) | −15.46 (− 31.20, 3.87) |
| MBzP2 | ||
| 17 (< 0.035) | Ref | Ref |
| 2 (0.035–0.102) | −9.43 (− 23.59, 7.36) | − 9.34 (− 23.43, 7.25) |
| 3 (0.102–0.27) | − 7.78 (− 23.28, 10.96) | −5.45 (− 21.34, 13.54) |
| 4 (> 0.27) | 3.46 (− 13.84, 24.23) | 4.39 (− 12.89, 25.23) |
| MEHP2 | ||
| 17 (< 6.95) | Ref | Ref |
| 2 (6.95–17.21) | − 13.32 (− 26.80, 2.53) | − 13.58 (− 26.88, 2.12) |
| 3 (17.21–36.01) | − 12.89 (− 26.95, 3.87) | −14.02 (− 27.75, 2.33) |
| 4 (> 36.01) | − 17.55 (− 31.34, − 0.90) | − 18.29 (− 31.89, − 1.98)* |
| MEHHP2 | ||
| 17 (< 10.94) | Ref | Ref |
| 2 (10.94–19.09) | −7.78 (− 23.05, 10.52) | − 7.41 (− 22.59, 10.74) |
| 3 (19.09–34.68) | 1.61 (−16.56, 23.61) | 1.71 (− 16.31, 23.61) |
| 4 (> 34.68) | − 3.63 (− 21.42, 18.18) | −5.07 (− 22.43, 16.18) |
| MEOHP2 | ||
| 17 (< 7.41) | Ref | Ref |
| 2 (7.41–15.34) | − 22.74 (− 35.14, − 7.87) | −23.74 (− 35.85, − 9.24) |
| 3 (15.34–27.72) | − 19.59 (− 33.17, − 3.25) | −19.91 (− 33.30, − 3.82) |
| 4 (> 27.72) | −17.80 (− 32.56, 0.20) | − 20.23 (− 34.43, − 2.96) |
| ∑DEHP2 | ||
| 17 (< 0.10) | Ref | Ref |
| 2 (0.10–0.19) | −9.43 (− 23.97, 7.90) | −11.04 (− 25.25, 5.87) |
| 3 (0.19–0.35) | −13.58 (− 28.18, 3.87) | − 14.10 (− 28.39, 3.15) |
| 4 (> 0.35) | −12.10 (− 27.75, 6.82) | − 13.76 (− 28.97, 4.71) |
| MOP3 | −2.76 (− 14.62, 10.74) | −1.78 (− 13.67, 11.74) |
*Tests for linear trend with P-value < 0.05. Statistically significant results comparing a specific category to the reference are bolded
1Serum INHB levels were natural logarithm transformed
2Phthalate metabolite concentrations were categorized into quartiles
3Dichotomous variable based on above/below limits of detection
4Model 1 was adjusted for age, BMI and creatinine
5Model 2 was adjusted for age, BMI, creatinine and PCO/PCOS diagnosis (yes or no)
6Percent change and 95% CI were calculated as follows: [exp (β)-1]*100
7Reference category