. Author manuscript; available in PMC: 2018 Jun 3.

Published in final edited form as: Biochem Biophys Res Commun. 2017 Apr 13;487(3):545–551. doi: 10.1016/j.bbrc.2017.04.067

Table 1.

Homology modeling of VWA8a and VWA8b

Template	Alignment Coverage	Confidence	% identity	Template Information
VWA8a (long isoform)

C3vkhB	19-1022 (52%)	100.0	16	PDB header: motor protein Chain: B: PDB Molecule: dynein heavy chain, cytoplasmic; PDB Title: x-ray structure of a functional full-length dynein motor domain
C3vkhA	20-1022 (52%)	100.0	16	PDB header: motor protein Chain: A: PDB Molecule: dynein heavy chain, cytoplasmic; PDB Title: x-ray structure of a functional full-length dynein motor domain
C4rh7A	19-1022 (52%)	100.0	14	PDB header: motor protein Chain: A: PDB Molecule: green fluorescent protein/cytoplasmic dynein 2 heavy chain PDB Title: crystal structure of human cytoplasmic dynein 2 motor domain in 2 complex with adp.vi
C3vkgA	20-1101 (56%)	100.0	14	PDB header: motor protein Chain: A: PDB Molecule: dynein heavy chain, cytoplasmic; PDB Title: x-ray structure of an mtbd truncation mutant of dynein motor domain
C3vkgB	19-1022 (52%)	100.0	15	PDB header: motor protein Chain: B: PDB Molecule: dynein heavy chain, cytoplasmic; PDB Title: x-ray structure of an mtbd truncation mutant of dynein motor domain

VWA8b (short isoform)

C4rh7a	86-1022 (90%)	100.0	15	PDB header: motor protein Chain: A: PDB Molecule: green fluorescent protein/cytoplasmic dynein 2 heavy chain PDB Title: crystal structure of human cytoplasmic dynein 2 motor domain in2 complex with adp.vi
C3vkhb	86-1022 (90%)	100.0	13	PDB header: motor protein Chain: B: PDB Molecule: dynein heavy chain, cytoplasmic; PDB Title: x-ray structure of a functional full-length dynein motor domain
C4akgB	86-1022 (90%)	100.0	14	PDB header: motor protein Chain: B: PDB Molecule: glutathione s-transferase class-mu 26 kDa isozyme, dynein PDB Title: dynein motor domain - atp complex
C3vkhA	86-1022 (90%)	100.0	13	PDB header: motor protein Chain: A: PDB Molecule: dynein heavy chain, cytoplasmic; PDB Title: x-ray structure of a functional full-length dynein motor domain
C4w8fA	86-1022 (90%)	100.0	14	PDB header: motor protein Chain: A: PDB Molecule: dynein heavy chain lysozyme chimera; PDB Title: crystal structure of the dynein motor domain in the amp pnp-bound state

Primary amino acid sequences of VWA8a and VWA8b were subjected to Phyre2 for homology modeling. Shown are the top 5 models for each isoform.