. Author manuscript; available in PMC: 2018 Feb 23.

Published in final edited form as: Thromb Haemost. 2016 Dec 22;117(3):618–624. doi: 10.1160/TH16-07-0519

Table 2.

Association of Baseline D-dimer with Cardiovascular Disease Risk

	Per Doubling D-dimer		Difference in HR (CHD – Stroke, 95% CI)
	CHD HR (95% CI)	Stroke HR (95% CI)	Difference in HR (CHD – Stroke, 95% CI)
Demographic Model^*
Entire cohort	1.32 (1.17, 1.50)	1.20 (1.07, 1.35)	0.12 (−0.04, 0.31)
Blacks	1.41 (1.19, 1.67)	1.18 (1.00, 1.40)	0.23 (0.01, 0.56)
Whites	1.24 (1.04, 1.48)	1.22 (1.03, 1.44)	0.02 (−0.20, 0.23)
p-interaction_{race* D-dimer}	0.30	0.80
Risk Factor Model^†
Entire Cohort	1.27 (1.11, 1.45)	1.15 (1.01, 1.31)	0.12 (−0.07, 0.33)
Blacks	1.33 (1.11, 1.59)	1.12 (0.92, 1.34)	0.20 (0.00, 0.58)
Whites	1.21 (1.01, 1.47)	1.19 (0.99, 1.42)	0.02 (−0.30, 0.27)
p-interaction_{race* D-dimer}	0.49	0.60

CHD: Adjusted for age, sex, region, and race

Stroke: Adjusted for age, sex, region, race, and age*race

^†

CHD: Adjusted for age, sex, region, race, systolic blood pressure, use of antihypertensive medications, diabetes, current smoking, total cholesterol, HDL cholesterol, and taking cholesterol-lowering medications

Stroke: Adjusted for age, sex, region, race, age*race, systolic blood pressure, use of antihypertensive medications, diabetes, current smoking, baseline cardiovascular disease, baseline atrial fibrillation, and baseline left ventricular hypertrophy