Table 3.

Biodistibution of ⁶⁸Ga-NODAGA-JR11, ⁶⁸Ga-DOTATOC and ⁶⁸Ga-DOTATATE in NOD scid gamma ZR-75-1 tumor-bearing mice

	68Ga-NODAGA-JR11 n = 5		68Ga-DOTATOC n = 6		68Ga-DOTATATE n = 6
	Mean	SD	Mean	SD	Mean	SD
Tumor	12.21	0.78	18.44	2.87 ***	15.22	2.20
Blood	0.80	0.10	0.45	0.09 ***	0.35	0.06 ***
Fat	0.23	0.11	0.18	0.09	0.28	0.15
Ovaries	0.67	0.22	0.51	0.07	0.89	0.35
Uterus	0.86	0.22	0.54	0.11	0.84	0.10
Intestines	0.90	0.20	2.39	0.30 ***	7.35	0.44 ***
Stomach	1.36	0.78	2.75	1.25	8.29	3.06 ***
Pancreas	9.29	2.03	11.01	1.32	51.56	5.47 ***
Spleen	0.39	0.05	0.46	0.11	0.84	0.38
Kidneys	14.12	1.65	9.27	1.73 ***	8.45	1.73 ***
Adrenals	2.00	0.65	9.52	3.78 **	15.20	7.26 **
Liver	0.99	0.12	0.71	0.17	1.95	0.52 ***
Lungs	4.72	0.71	22.93	6.12 ***	28.66	2.94 ***
Heart	0.46	0.06	0.30	0.04 *	0.67	0.13 **
Muscle	0.28	0.07	0.11	0.02 ***	0.11	0.04 ***
Bone	0.26	0.04	0.20	0.03	0.25	0.03
Brain	0.05	0.02	0.03	0.01	0.03	0.01
Tumor to Background Ratios
Blood	15.56	2.20	41.13	5.68 ***	44.65	11.74 ***
Muscle	45.15	11.56	171.51	55.33 **	151.95	60.75 **
Kidneys	0.87	0.12	2.01	0.24 ***	1.88	0.48 ***

Organ uptake is expressed as mean ± standard deviation (SD) in units of percent injected dose per gram of tissue (%ID/g). The tumor uptake is highlighted in bold. Means were statistically compared to the respective organ uptake of ⁶⁸Ga-NODAGA-JR11 and p values < 0.05, < 0.01, and < 0.001 were expressed as *, ** and *** respectively