Table 3.

^99mTc production pathways

Reaction	Method	Currently available	Status and further development
235U(n,f)99Mo → 99mTc	Reactor + generator	Worldwide	Well-established, availability will shrink with phasing out of nuclear research reactors
100Mo(p,2n)99mTc	Small medical or intermediate energy cyclotron	In Canada	Possible worldwide implementation with decreasing nuclear reactor capacity
96Zr(α,n)99Mo → 99mTc	α beam cyclotron + generator	No	Will not be implemented. Method not competitive, α-beam required, low yields
100Mo(γ,n)99Mo → 99mTc	LINAC+ generator	No	Under development in Canada, USA and the Netherlands
98Mo(n,γ)99Mo → 99mTc	Reactor + generator	In USA and Japan	Auxiliary method used in nuclear reactors (Blaauw et al., 2017; van der Marck, Koning, and Charlton, 2010). Availability will shrink with phasing out of nuclear research reactors
100Mo(p,2n)99mTc	Laser	No	Theoretically feasible. Further research required