Table 3.
Association of HP genotypes with blood lipid levels in Chinese
| Blood lipids | No. of subjects | Geometric meana (mg/dL) | Difference (mg/dL) | Pb |
|---|---|---|---|---|
| Total Cholesterol | ||||
| HP2-HP2 | 1,553 | 179.81 (177.93–181.71) | Reference | |
| HP1-HP2 | 1,606 | 179.15 (177.37–180.94) | −1.27 | 0.31 |
| HP1-HP1 | 449 | 175.36 (171.85–178.95) | −4.24 | 0.02 |
| HP1S-HP1S | 359 | 173.97 (170.25–177.78) | −5.59 | 0.007 |
| LDL Cholesterol | ||||
| HP2-HP2 | 1,552 | 97.38 (95.82–98.97) | Reference | |
| HP1-HP2 | 1,605 | 97.83 (96.37–99.31) | 0.11 | 0.92 |
| HP1-HP1 | 449 | 93.83 (90.93–96.82) | −3.43 | 0.03 |
| HP1S-HP1S | 359 | 92.55 (89.37–95.85) | −4.68 | 0.008 |
| HDL Cholesterol | ||||
| HP2-HP2 | 1,552 | 48.95 (48.35–49.56) | Reference | |
| HP1-HP2 | 1,606 | 49.31 (48.71–49.90) | 0.38 | 0.38 |
| HP1-HP1 | 449 | 48.53 (47.35–49.75) | −0.49 | 0.45 |
| HP1S-HP1S | 359 | 48.13 (46.85–49.45) | −0.87 | 0.23 |
| Triglycerides | ||||
| HP2-HP2 | 1,552 | 137.24 (133.08–141.54) | Reference | |
| HP1-HP2 | 1,606 | 132.09 (128.45–135.84) | −6.51 | 0.01 |
| HP1-HP1 | 449 | 134.19 (126.69–142.14) | −2.18 | 0.59 |
| HP1S-HP1S | 359 | 134.94 (126.51–143.92) | −1.62 | 0.72 |
a
Geometric mean and 95% CI
b
Derived from linear regression models using log-transformed data with adjustments for age and data sources, compared to the HP2-HP2 genotype