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. Author manuscript; available in PMC: 2018 Feb 23.
Published in final edited form as: Nat Neurosci. 2017 Feb 6;20(3):396–405. doi: 10.1038/nn.4493

Figure 6.

Figure 6

Emergence of glioma subpopulations correlates with seizures. (a) Schematic for time course of tumor progression in the CRISPR model. (b–d) Representative EEG recordings from mice containing tumors at P30 (b), P50 (c) and P70 (d); note the progressive cortical hyperexcitability during tumor progression (n = 6 for each timepoint). y axes denote millivolts. (e–g) Pie charts showing the representative subdivision of the GFP+ tumor cells into populations A–D (and other) during the P30–P70 progression interval (n = 6 for each timepoint). (h) Quantification of the interictal spike activity at each time point during tumor progression (n = 6 animals for each time point). *P = 0.0049, **P = 0.0143, ***P = 0.0041 and ****P = 0.0014; by one-way ANOVA and followed by Tukey’s test for between-group comparisons. (i) Quantification of the glioma subpopulation constitution (n = 5 tumors for each time point. Throughout, data are mean ± s.e.m.