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. Author manuscript; available in PMC: 2018 Feb 23.
Published in final edited form as: Mol Cell. 2016 Oct 20;64(3):455–466. doi: 10.1016/j.molcel.2016.09.002

Figure 4. The Tail Module Contributes to PIC Assembly/Stability to a Similar Extent in SAGA- and TFIID-Dominated Genes.

Figure 4

(A) Cumulative plot of the change in TFIIB promoter occupancy in med18-AA cells after a 90 min treatment with rapamycin (solid trace) and in med3Δ/med15Δ cells (TailΔ, dashed trace), relative to their respective WT. All genes with a TFIIB log2 ratio > 2 were used in this analysis.

(B) Cumulative plot of the change in TFIIB promoter occupancy in med3Δ/med15Δ cells (TailΔ) cells, relative to WT, for the SAGA-dominated (red) and TFIID-dominated (blue) genes with a TFIIB log2 ratio > 2.

(C) Cumulative plot of the change in TFIIB promoter occupancy in med18-AA cells after a 90 min treatment with rapamycin, relative to WT, for the SAGA-dominated (red) and TFIID-dominated (blue) genes with a TFIIB log2 ratio > 2 (high TFIIB, solid traces) or for genes having equivalent TFIIB levels between the SAGA- and TFIID-dominated gene groups (equivalent TFIIB, dashed traces).

(D) Distribution of TFIIB occupancy at the promoter of SAGA-dominated genes (red) and TFIID-dominated genes (blue).

See also Figure S4.