a) All-atom model of the mature HIV-1 capsid core, determined by an integrated cryo-EM, cryo-ET, solution NMR, and MD approach (PDBID: 3J3Y [41]). b) 3D structure of an HIV-1 CA monomer (PDBID: 3NTE [45]). c) Transmission electron microscopy (TEM) image of the NMR sample of tubular assemblies of U-13C,15N CA (NL4-3 variant). dāf) 2D (H)CH HETCOR (d) and (H)NH HETCOR (e) spectra, and representative 13C planes of a 3D (H)CANH 1H-detected spectrum (f) of tubular assemblies of U-13C,15N CA, recorded at 19.96 T (850 MHz) and a MAS frequency of 110 kHz.