Skip to main content
. 2018 Feb 21;38(8):1959–1972. doi: 10.1523/JNEUROSCI.1931-17.2018

Figure 2.

Figure 2.

Recording of electrically stimulated DA efflux in striatal brain slices from DAT-KO rats. A, A single biphasic stimulus (400 μA, 1 ms) was used to evoke DA release in striatal brain slices from WT, DAT-HET, and DAT-KO rats. The average time to clear released DA was 1.3, 10, and 50 s respectively. Bottom, Color plot representing the voltammetric currents (encoded in color in the z-axis) plotted against the applied potential (y-axis) and time (x-axis). Top, Cyclic voltammogram identifying the detected analyte as DA. B, Kinetics of evoked DA release in DStr of DAT WT, DAT-HET, and DAT-KO. C, D, Effect of 3 μm COC on evoked DA release. COC had no effect on evoked DA overflow in DAT-KO rat but induced the well known increase in DA overflow in both WT and DAT-HET (C) COC-induced changes in extracellular DA half-life (D). E, Fluoxetine (10 μm) effect on evoked DA release. F, Tolcapone (10 μm) effect on DA release. G, Pargyline (10 μm) effect on evoked DA release (n = 5–6 per each group, *p < 0.05; **p < 0.01; ***p < 0.001).