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. 2018 Feb 20;11:891–901. doi: 10.2147/OTT.S154754

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© 2018 Shen et al. This work is published and licensed by Dove Medical Press Limited

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CDCA5 knockdown downregulates CCNB1 and CDK1.

Notes: (A) CDK1 (left panel) and CCNB1 (right panel) protein expression were determined in Huh-7 cells using Western blotting following transfection with sh-CDCA5 or sh-Ctrl lentiviruses. GAPDH was used as a loading control. (B) CDK1 and CCNB1 mRNA expression levels in HCC tissues (n=369) and normal liver tissues (n=50) were analyzed based on CDCA5 expression data in the TCGA cohort through the GEPIA website (*P<0.05). (C) Correlations between CDCA5 levels and CDK1 and CCNB1 expression, respectively, were generated from data of the TCGA cohort through the GEPIA website using the person method (*P<0.05).

Abbreviations: CCNB1, CyclinB1; CDK1, cyclin-dependent kinase 1; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GEPIA, Gene Expression Profiling Interactive Analysis; HCC, hepatocellular carcinoma; sh-Ctrl, control; TCGA, the Cancer Genome Atlas.