Table 8.

Effect of different gel formulations on the degree of orthokeratosis, drug activity, and reduction in epidermal thickness in mouse tail model after topical application for 4 weeks

Groups	Orthokeratosis (%)	Drug activity (%)	Reduction in epidermal thickness (%)
Control (normal tail)	11.20±2.10	–	–
Plain gel	12.31±2.37	1.25	9.25±2.09
Zarotex gel (0.1%; commercial product)	34.13±3.76*	25.82	22.64±3.08
Act gel	41.42±3.46*	34.03	59.49±3.48
Act niosomal gel	68.51±3.22*,**	64.54	73.60±2.32**

Notes: Each value represents the mean ± SE (n=6).

^*p<0.05 vs control;

^**p<0.05 Act niosomal gel vs other gel formulations.

Abbreviation: Act, Acitretin.