Table 1.

Summary of studies looking retrospectively at baseline FC levels in patients who relapse or stay in remission

	Authors	Disease type	Patients (n)	Definition of relapse	Median FC levels		p Value	FC cut-off	Sensitivity (%)	Specificity (%)	Relapse risk
Year					Relapse/active disease group	Non-relapse/remission group
2000	Tibble et al 24	CD	43	CDAI>150 and rise>100	122 mg/L	42 mg/L	<0.0001	50 mg/L*	90	83
		UC	37	HBI>4 and rise>2	123 mg/L	29 mg/L	<0.0001
2005	Costa et al 12	CD	38	CDAI>150 and new Rx	220.1 μg/g	220.5 μg/g	0.395	150 μg/g	87	43	2
		UC	41	UCAI>4 and new Rx	220.6 μg/g	67 μg/g	<0.0001	150 μg/g	89	82	14
2008	D'Inca et al 13	CD	65	CDAI>150 and rise>50	207 mg/kg	88 mg/kg	0.055	130 mg/kg	65	62	1.7
		UC	97	ET>4 and new Rx	190 mg/kg	49 mg/kg	0.02	130 mg/kg	70	70	2.4
2009	Gisbert et al 25	CD	89	CDAI>150	266 μg/g	145 μg/g	0.002	150 μg/g	28	93
		UC	74	Modified TWI>11	213 μg/g	126 μg/g	0.03	150 μg/g	31	91
2010	Garcia-Sanchez et al 26	CD	66	CDAI>150	524 μg/g	123 μg/g	<0.01	200 μg/g	80	65	4
		UC	69	Modified TWI≥11	298 μg/g	105 μg/g	<0.01	120 μg/g	81	63	6
2010	Kallel et al 27	CD	53	CDAI>150 or rise>100	380.5 μg/g	155 μg/g	<0.001	340 μg/g	80	90.7	18.8
2010	Sipponen and Kolho14	IBD	72	PGA	409 μg/g	282 μg/g	0.44	108.5 μg/g	38	72
2011	Laharie et al 15	CD	50	CDAI>150 and rise>70	200 μg/g	150 μg/g	ns	130 μg/g	61	48
2013	Lasson et al 28	UC	69	New treatment	263 μg/g	102 μg/g†	0.009	262 μg/g	64.4	70.8
2013	De Vos et al 29	UC	87	New treatment, Mayo≥2	125 mg/kg‡	27 mg/kg‡	<0.001	300 mg/kg	58.3	93.3
2014	Naismith et al 30	CD	92	New treatment, surgery	414 μg/g	96 μg/g	0.005	240 μg/g	80	74.4	12.2
2015	Ferreiro-Iglesias et al 16	CD	37	HBI>4	625 μg/g	45 μg/g	<0.005	204 μg/g	100	85.7
2015	Ferreiro-Iglesias et al 17	CD	33	HBI>4	287 μg/g	94 μg/g	<0.005	160 μg/g	87.5	84
		UC	20	PMI>2	420 μg/g	136 μg/g	<0.005	198 μg/g	100	81.3
2015	Scaioli et al 31	UC	74	SCCAI>3	218 μg/g	48 μg/g	<0.01	193 μg/g	65	98
2015	Mooiweer et al 32	IBD	72	New Rx, admission and endoscopic activity	284 mg/kg	37 mg/kg	<0.01	56 mg/kg§	64	100
2016	Delefortrie et al 33	CD	29	Not stated	261.5 μg/g	37.6 μg/g	<0.05	106.5 μg/g	87.5	95.2
2016	Zittan et al 34	IBD	58	SES-CD≥3 and MES=0	1180 μg/g	100 μg/g	<0.0001	100 μg/g¶	71	91

*Combined CD and UC.

†Mild disease activity.

‡Mean values.

§Predict absence of relapse.

¶Predict endoscopic remission.

CD, Crohn's disease; CDAI, Crohns Disease Activity Index; ET, Edwards and Truelove score; FC, faecal calprotectin; HBI, Harvey–Bradshaw Index; IBD, inflammatory bowel disease; MES, Mayo endoscopic score; ns, non-significant; PGA, Physician's Global Assessment; PMI, partial Mayo index; Rx, treatment; SCCAI, Simple Clinical Colitis Activity Index; SES, simple endoscopic score; TWI, Truelove and Witt Index; UC, ulcerative colitis.