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. 2018 Feb 23;8:3527. doi: 10.1038/s41598-018-21421-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Alliin does not change the whole-body energy metabolism in DIO mice. Alliin did not affect (a) the physical activity, (b) the respiratory exchange ratio, (c) energy intake or (d) energy expenditure. No significant difference of (e and f) the core body temperature between alliin treated and the control DIO mice under cold condition. Both (g) the sagittal view of PET-CT images and (h) quantified SUV showed that alliin treatment did not affect brown adipose tissue activity in DIO mice. Data are means ± SEM (n = 6). Yellow triangle: anatomic site of interscapular BAT. SUV, standard uptake value.