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. 2018 Feb 23;8:3533. doi: 10.1038/s41598-018-21521-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pb accumulation in the hippocampus and its effect on learning and memory on PND30 rats. Morris water maze test was performed to detect learning and memory ability in four groups of animals: Control, 0.005% Pb, 0.01% Pb and 0.02% Pb. (a) Body weights (N = 8 per group) and (b) blood-lead-levels (BLLs) (N = 8 per group) were measured at postnatal day (PND) 0, 3, 7, 10, 14, 21 and 30. (c) Hippocampal Pb levels (N = 8 per group) and (d,e) the water maze test (N = 8 per group) were only measured at PND 30. Test results showed that with increased Pb exposure, the escape latencies were positively correlated, and time spent in the targeted quadrant at the test day were negative correlated. Data are expressed as mean ± SD, *p < 0.05, **p < 0.01.