Table 3.

Pearson correlation coefficients between the global lactate-to-pyruvate ratio and other experimental parameters.

	Correlation between Lactate-to-Pyruvate Ratio and other Parameters
	Parameter	r	95% C.I.	p -value
Final imaging data only	Pulmonary Compliance	−0.581	−0.709, −0.413	<0.001*
	Oxygen Saturation	−0.687	−0.789, −0.553	<0.001*
	Infiltration Score	0.509	0.100, 0.771	0.018
	Alveolar Structure Damage	0.485	0.068, 0.758	0.025
	Hyaline Membrane Score	0.612	0.245, 0.825	0.003*
	Edema Score	0.663	0.325, 0.851	0.001*
	ICAM-1 Expression	0.782	0.529, 0.907	<0.001*
	Myeloperoxidase Activity	0.817	0.589, 0.921	<0.001*

Pulmonary compliance and oxygen saturation was measured at the beginning of carbon-13 imaging. Histological features were only correlated with the last imaging time-point. Bonferroni correction was applied for 8 univariate correlation tests (significance for adjusted α_adj. = 0.05/8 = 0.00625).