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. 2018 Feb 23;8:3562. doi: 10.1038/s41598-018-21951-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The peptidomimetic G3 acts on agr likely via interception of the AIP-AgrC interaction. Assessment of competitive action of G3 in a P3-blaZ reporter strain when applying (A) increasing concentrations of G3 with a fixed AIP concentration (10% AIP containing supernatant) and (B) increasing percentages of AIP containing supernatant with a fixed G3 concentration (3 μg/ml). The bars represent the mean values (±SD) of technical replicates of samples collected 45 minutes after addition of the AIP containing supernatant. The inhibitory effect of G3 on a strain expressing a constitutively active AgrC variant (RN10829 Const.) was assessed by treating with 3 μg/ml of the analogue (C) using DMSO as a control. The data represent the mean (±SD) of 3 biological triplicates of samples obtained 60 minutes after the addition of the peptidomimetic.