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. 2018 Feb 23;8:3529. doi: 10.1038/s41598-018-21389-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cytokine production according to PD-1 and CD57 expression. (A) Summary of relative abundance of CD4+ T cells expressing the indicated cytokines in tonsil and blood, determined by intracellular staining and flow cytometry of paired samples from individual donors (n = 7, except for IL-21 where n = 4). (B) Summary of relative abundance of intracellular cytokines in purified CD4+ T cell subsets defined in Fig. 1H. Each symbol indicates a result from a different donor (IL-4, n = 2; IL-17, n = 4; IFN-γ, n = 4; IL-10, n = 3; IL-21, n = 5). (C) Summary of relative abundance of IL-21 (n = 5) and IL-10 (n = 4) positive cells in peripheral blood subsets. (D) Summary of abundance of IL-21 producing cells in each indicated CD4+ T cell subset from tonsil (n = 5) or blood (n = 4), analysed according to CXCR5 expression. *p < 0.05; **p < 0.01, ***p < 0.001.