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. 2018 Jan 29;128(3):931–943. doi: 10.1172/JCI97229

Figure 6. Immune cells infiltrate the brain after microglia depletion.

Figure 6

Mice were treated with PLX5622-containing or control feed for 7 days prior to intracranial infection with 700 PFU MHV. Cells from brains and DCLNs were assessed on the indicated days p.i. (A and D) Representative flow plots show CD45+ cell populations in the brain on the indicated days p.i. Graphs show a summary of flow cytometric data on cells isolated from mouse brains (A, B, D, and E) and DCLNs (C and F) on day 3 (A–C) or day 7 (D–F) p.i. Data represent the mean ± SEM and are from 3 independent experiments, with a combined total of 8 to 9 mice per group. Statistical significance was determined using Mann-Whitney U tests. *P < 0.05.