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. 2018 Feb 12;128(3):1087–1105. doi: 10.1172/JCI97794

Figure 5. Vhl-deficient mice develop increased glucose tolerance and low glycemia despite greatly reduced production and levels of osteocalcin in their bones and serum.

Figure 5

(A and B) Serum osteocalcin (Ocn) levels in (A) control and constitutive Vhl cKO mice (n = 9–14) and (B) control and PN–Vhl cKO mice (n = 7–8.). (C and D) Ocn mRNA levels in bones of (C) 12-week-old control and constitutive Vhl cKO mice (n = 7) and (D) 24-week-old control and PN–Vhl cKO mice (n = 6–8). (E) Ocn mRNA levels in osteoblasts derived from Vhl-floxed mice and transduced with AdEmpty or AdCre in vitro (also see Figure 6) (n = 5). All data were obtained in male mice. Graphs represent mean ± SEM, and *P < 0.05, **P < 0.01, ***P < 0.001 by Student’s t test between genotypes, unless indicated otherwise.