Figure 1. Seizures induce ataxic breathing in a patient with DS.

(A and B) Irregular breathing during and after a seizure. Video frame (A) from Supplemental Video 1 showing region of interest (vertical line pointed to by arrow) used to visualize respiratory movements. Using the methods illustrated in Supplemental Figure 1A, respiratory movements were plotted during and after a generalized seizure (B; traces are contiguous). During the seizure (first 13 seconds), most inspirations had more than one peak. Immediately after the seizure, there was a respiratory pause followed by continued abnormal inspirations lasting until 32 seconds postictal. A normal breathing pattern then resumed with regular, monophasic inspiratory efforts.