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. 2018 Feb 5;128(3):1010–1025. doi: 10.1172/JCI95802

Figure 10. Schematic for the positive feedback loop linking Hippo/YAP/TAZ and IRS2/AKT signaling in the liver of DKO (Pten–/– Sav1–/–) mice.

Figure 10

Hippo signaling interacts with AKT signaling by regulating IRS2 expression and prevents NAFLD and liver cancer progression.