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. 2018 Feb 23;8:3518. doi: 10.1038/s41598-018-21815-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of Aβ42 and isoAβ42 (10 µM) on SH-SY5Y cells. (A) Visualization of the cells using fluorescent microscopy. Left, untreated cells. Centre, cells treated with Aβ42. Right, cells treated with isoAβ42. Arrows indicate the following: 1 - apoptotic cells stained with Hoechst 33342; 2 - living cells; 3 - necrotic cells stained with propidium iodide. Scale is 20 µm. (B) Number of apoptotic cells in the cell population. Control - untreated cells; isoAβ42 and Aβ42 - cells treated with isoAβ42 and Aβ42 for 24 h, respectively. (C) Viability of the cells in percent, revealed by MTT-test treated with Aβ42 or isoAβ42 relative to control without treatment at 48 h. Each value represents mean ± SD of at least three independent experiments performed in quadruplicate; *p < 0.023, **p < 0.002, ***p < 0.001, ^#p < 0.005, ^##p < 0.003, ^###p < 0.001.