Fig. 1.

ZUFSP and Mug105 are related to UFM1/Atg8 proteases. a Structurally correct alignment of the catalytic domains of human ZUFSP (this work), mouse UFSP2 (3OQC) and human ATG4A (2P82). The S. pombe Mug105 sequence was added by sequence similarity to ZUFSP. Invariant and conservatively replaced residues are shown on black or gray background, respectively. Catalytic residues are highlighted in blue. b Conservation of the four UBZ-like zinc fingers of ZUFSP, in comparison to the structurally characterized UBZ finger (3WUP). c Conservation of the MIU domain of ZUFSP, in comparison to other human MIU domains