Table III.

Logistic regression analysis of risk factors for post-ERCP pancreatitis (PEP) in patients with or without a history of pancreatitis

Patients with previous PEP	OR (95%CI)	P value
Univariate analysis
Total procedure time (< 30 min vs. ≥ 30 min)	3.65 (1.33–11.30)	0.01
Cannulation time (< 15 min vs. ≥ 15 min)	3.13 (1.22–8.42)	0.02
Pancreatic duct injection (performed vs. not performed)	4.00 (1.15–18.74)	0.03
Multivariate analysis*
Cannulation time (< 15 min vs. ≥ 15 min)	2.97(1.10–8.43)	0.03
Pancreatic duct injection (performed vs. not performed)	4.28(1.16–20.78)	0.03
Patients with previous acute pancreatitis	OR (95%CI)	P value
Univariate analysis
Total procedure time (< 30 min vs. ≥ 30 min)	3.86 (1.12–15.90)	0.03
Multivariate analysis*
Total procedure time (< 30 min vs. ≥ 30 min)	3.93 (1.11–16.46)	0.03
Patients without previous pancreatitis	OR (95%CI)	P value
Univariate analysis
Suspected SOD (presence vs. absence)	8.61 (2.96–22.35)	0.0003
Cannulation time (< 15 min vs. ≥ 15 min)	2.21 (1.30–3.70)	0.004
Multivariate analysis*
Suspected SOD (presence vs. absence)	10.48 (3.52–28.08)	0.0001
Cannulation time (< 15 min vs. ≥ 15 min)	2.43 (1.41–4.14)	0.002

^*The odds ratio was adjusted for age, sex, suspected SOD, cannulation time, total procedure time, pancreatic duct injection, EST, precut sphincterotomy, pancreatic duct IDUS, bile duct IDUS, pancreatic duct aspiration cytology, bile duct aspiration cytology, pancreatic duct brush cytology, bile duct brush cytology, and EPS. Backward stepwise elimination with a threshold of P = 0.05 was used to select variables for the final models.

EPS: endoscopic pancreatic stenting; ERCP: endoscopic retrograde cholangiopancreatography; EST: endoscopic sphincterotomy; IDUS: intraductal ultrasonography; SOD: sphincter of Oddi dysfunction. CI, confidence interval; OR, odds ratio.