Table II.
Physical compatibility of drugs in a mixture.
| (A) Nab-paclitaxel and gemcitabine hydrochloride
| ||||||
|---|---|---|---|---|---|---|
| Storage period (h) | 0 | 1 | 2 | 4 | 8 | 24 |
| pH values * | 3.95 ± 0.01 | 3.96 ± 0.01 | 3.94 ± 0.01 | 3.94 ± 0.01 | 3.93 ± 0.01 | 3.95 ± 0.01 |
| Color and appearance | white turbidity | NC | NC | NC | NC | NC |
| Precipitation | ND | ND | ND | ND | ND | ND |
| (B) Nab-paclitaxel and carboplatin
| ||||||
|---|---|---|---|---|---|---|
| Storage period (h) | 0 | 1 | 2 | 4 | 8 | 24 |
| pH values * | 6.75 ± 0.01 | 6.75 ± 0.01 | 6.74 ± 0.01 | 6.72 ± 0.01 | 6.72 ± 0.01 | 6.73 ± 0.01 |
| Color and appearance | white turbidity | NC | NC | NC | NC | NC |
| Precipitation | ND | ND | ND | ND | ND | ND |
| (C) Nab-paclitaxel and dexamethasone sodium phosphate
| ||||||
|---|---|---|---|---|---|---|
| Storage period (h) | 0 | 1 | 2 | 4 | 8 | 24 |
| pH values * | 7.43 ± 0.01 | 7.43 ± 0.01 | 7.44 ± 0.01 | 7.45 ± 0.01 | 7.47± 0.01 | 7.49 ± 0.01 |
| Color and appearance | white turbidity | NC | NC | NC | NC | NC |
| Precipitation | ND | ND | ND | ND | ND | ND |
| (D) Nab-paclitaxel and granisetron hydrochloride
| ||||||
|---|---|---|---|---|---|---|
| Storage period (h) | 0 | 1 | 2 | 4 | 8 | 24 |
| pH values * | 5.90 ± 0.01 | 5.91 ± 0.01 | 5.92 ± 0.01 | 5.93 ± 0.01 | 5.96 ± 0.01 | 6.00 ± 0.01 |
| Color and appearance | white turbidity | NC | NC | NC | NC | NC |
| Precipitation | ND | ND | ND | ND | ND | ND |
| (E) Nab-paclitaxel and palonosetron hydrochloride
| ||||||
|---|---|---|---|---|---|---|
| Storage period (h) | 0 | 1 | 2 | 4 | 8 | 24 |
| pH values * | 5.38 ± 0.01 | 5.38 ± 0.01 | 5.39 ± 0.01 | 5.40 ± 0.01 | 5.44 ± 0.01 | 5.46 ± 0.01 |
| Color and appearance | white turbidity | NC | NC | NC | NC | NC |
| Precipitation | ND | ND | ND | ND | ND | ND |
| (F) Nab-paclitaxel, dexamethasone sodium phosphate and granisetron hydrochloride
| ||||||
|---|---|---|---|---|---|---|
| Storage period (h) | 0 | 1 | 2 | 4 | 8 | 24 |
| pH values * | 6.90 ± 0.01 | 6.91 ± 0.01 | 6.92 ± 0.01 | 6.93 ± 0.01 | 6.94 ± 0.01 | 6.96 ± 0.01 |
| Color and appearance | white turbidity | NC | NC | NC | NC | NC |
| Precipitation | ND | ND | ND | ND | ND | ND |
| (G) Nab-paclitaxel, dexamethasone sodium phosphate and palonosetron hydrochloride
| ||||||
|---|---|---|---|---|---|---|
| Storage period (h) | 0 | 1 | 2 | 4 | 8 | 24 |
| pH values * | 6.22 ± 0.01 | 6.23 ± 0.01 | 6.24 ± 0.01 | 6.23 ± 0.01 | 6.26 ± 0.01 | 6.31 ± 0.01 |
| Color and appearance | white turbidity | NC | NC | NC | NC | NC |
| Precipitation | ND | ND | ND | ND | ND | ND |
*
mean ± SD; n = 5, NC: no change, ND: not detected