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. 2018 Feb 23;8:3541. doi: 10.1038/s41598-018-21894-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Severe movement defects were induced by maternal ZIKV infection. (a) Representative images of P14 offspring mice. The hind limbs of ZIKV-infected mice were paralyzed. (b) Quantification of the paralysis rate during P0-P28. (c) Representative images of lumbar spinal cords stained for Cas3 and ZIKV. White arrows, cavities. (d) Percentage of Cas3-positive cells within lumbar spinal cords. n^Mock = 4, n^ZIKV = 8, n^DENV-2 = 4 samples from three independent experiments. (e) Representative image of a P14 spinal cord to illustrate the different segments. (f) Nissl staining of P14 cervical, thoracic, and lumbar spinal cord. (g) Representative images of the cerebellum stained for Cas3 and ZIKV. Quantification data are presented as the mean ± SEM. One-way ANOVA with Bonferroni’s post hoc test, **p < 0.01, ***p < 0.001.