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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Vet Comp Oncol. 2017 Apr 11;16(1):55–68. doi: 10.1111/vco.12311

Table 4.

Effects of JAK2- and STAT5 inhibitors on proliferation of canine neoplastic mast cells

IC50 values1 (μM) obtained with
Cells R763 TG101348 AZD1480 Ruxolitinib Pimozide Piceatannol
C2 0.005-0.01 0.25-0.75 1-2 10-20 0.5-1 17.5-25
NI-1 0.005-0.01 0.1-0.5 1-2 10-20 1-2.5 10-15
MCT #1 0.01-0.05 1-2 0.1-0.5 >20 0.5-1 25-50
MCT #2 0.005-0.01 1-2 1-2 >20 2.5-5 25-50
MCT #3 0.01-0.05 0.5-1 0.1-0.5 10-20 0.5-1 25-50

Abbreviations: IC, inhibitory concentration; MCT, mast cell tumor.

1

Assessed by 3H-thymidine uptake.