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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Hypertension. 2017 Dec 26;71(2):e1–e8. doi: 10.1161/HYPERTENSIONAHA.117.10271

Figure 3. Potential model for the role of VEGFR in the endothelial response to fluid shear stress.

Figure 3

Fluid shear stress activates mechanosensory complexes to affect endothelial activation and function. In one mechanosensory unit, platelet endothelial cell adhesion molecule 1 (PECAM-1) transmits changes in endothelial cytoskeletal structure to VEGFR2 and VEGFR3, through vascular endothelial cadherin (VE-cadherin). VEGFR2 and VEGFR3 are then activated in a ligand-independent fashion to mediate intracellular signaling changes.