Fig 1. Association of ceDNA, circulating nucleosomes, and NETs with VTE extent.

(A) CeDNA and (B) circulating nucleosomes in plasma correlated with the extent of VTE. (C) Plasma levels of the NET-specific biomarker, DNA-histone-MPO complexes, did not significantly correlate with VTE extent. Extent of acute VTE was categorized as isolated distal DVT only (n = 51), proximal DVT ± distal DVT (n = 133), and PE ± DVT (n = 427). All VTE (n = 611). FU: Fluorescent units; OD: Optical density. Data is shown as median ± inter-quartile range. P-values were calculated using a nonparametric test for trend across ordered groups.