Table 1. Blood gas levels were not different between paired WT and knockout groups at baseline, during hypercapnia, or during isocapnic hypoxemia.

Baseline (21% O2, 0% CO2, balance N2)
	WT	ASIC1-/-	WT	ASIC2-/-	WT	ASIC3-/-
PaO2	63.2 ± 0.9	66.4 ± 0.8	58.6 ± 1.0	62.1 ± 2.2	64.9 ± 0.9	70.9 ± 2.7
PaCO2	28.0 ± 1.1	26.2 ± 0.5	28.4 ± 0.3	29.3 ± 1.0	27.4 ± 0.8	26.7 ± 1.2
pHa	7.37 ± 0.01	7.39 ± 0.01	7.38 ± 0.01	7.39 ± 0.01	7.36 ± 0.01	7.34 ± 0.02
Hypercapnia (21% O2, 6.0% CO2, balance N2)
	WT	ASIC1-/-	WT	ASIC2-/-	WT	ASIC3-/-
PaO2	100.2 ± 2.1*	99.6 ± 2.1*	90.3 ± 1.2*	95.9 ± 2.9*	100.1 ± 1.4*	103.6 ± 3.5*
PaCO2	45.9 ± 1.5*	45.8 ± 0.8*	44.8 ± 0.7*	45.5 ± 0.9*	47.9 ± 0.9*	45.8 ± 0.9*
pHa	7.23 ± 0.02*	7.22 ± 0.01*	7.23 ± 0.01*	7.24 ± 0.02*	7.21 ± 0.01*	7.20 ± 0.02*
Isocapnic hypoxemia (7.0% O2, 3.2% CO2, balance N2)
	WT	ASIC1-/-	WT	ASIC2-/-	WT	ASIC3-/-
PaO2	40.3 ± 1.5*	40.4 ± 0.6*	35.6 ± 1.2*	38.5 ± 1.4*	39.3 ± 0.8*	42.7 ± 1.5*
PaCO2	25.5 ± 0.8*	25.1 ± 0.5	25.6 ± 0.4*	26.1 ± 0.7*	28.0 ± 0.6	27.3 ± 0.6
pHa	7.39 ± 0.02	7.39 ± 0.00	7.40 ± 0.01	7.40 ± 0.02	7.35 ± 0.02	7.32 ± 0.2

Arterial blood gas levels were assessed in samples taken from conscious, unrestrained mice chronically instrumented with femoral artery catheters at baseline (room air) or during exposure to 6% inspired CO₂ or 7% O₂, 3.2% CO₂ to induce hypercapnia or isocapnic hypoxemia, respectively. No differences in P_aO₂, P_aCO₂, or pH_a between paired WT and knockout groups were detected. Values are means ± SE; n = 5–8 animals/group.

*P < 0.05 vs. baseline (2-way, repeated measures ANOVA; Sidak’s post-hoc test).