Table 1. Agonistic and antagonistic activities of the peptidomimetics against BdNTLR.
| Chemical ID | Sequence information | AG (%) | ANT (%) |
|---|---|---|---|
| 1887[Φ1]wp-3 | pEA[Aib]S[Aib]FL[Aib]VRa | -2.09 (± 1.16) | 9.03 (± 14.41) |
| 1888[Φ1]wp-4 | pEA[Aib]SGFL[Aib]VRa | 1.01 (± 1.70) | 3.89 (± 13.74) |
| 2098[Φ3]wp-1 | TE[Aib]NPFW[Aib]NRa | 5.63 (± 2.17) | -2.08 (± 7.41) |
| 2065-SP2[Φ1]wp-1 | pQE[Aib]GPFW[Aib]NRa | 3.03 (± 1.43) | 0.24 (± 3.31) |
| 2131[Φ1]wp-4 | KEN[Aib]PNFW[Aib]SRa | 2.45 (± 0.20) | 2.87 (± 2.58) |
| 2102[Φ2]wp-2 | NLFQV[Aib]D[Aib]FF[Aib]TRa | -0.16 (± 1.62) | 10.95 (± 11.21) |
| 2104[Φ1]wp-2 | TE[Aib]N[Aib]FW[Aib]NRa | 10.03 (± 2.14) | -21.78 (± 28.18) |
| 2120[Φ1]wp-1 | NLFQV[Aib]DPFF[Aib]TRa | -0.64 (± 0.88) | 31.25 (± 2.13) |
| 2108[Φ1]wp-1 | SVR[Aib]DPTY[Aib]ARa | 7.98 (± 7.60) | -12.86 (± 1.87) |
| 2111[Φ1]wp-1 | AEGD[Aib]DYFW[Aib]TRa | 4.76 (± 0.73) | -4.42 (± 9.08) |
| 2130[Φ3]wp-2 | SVR[Aib]D[Aib]TY[Aib]ARa | 1.31 (± 0.66) | -2.20 (± 10.29) |
| 2069[Φ2]wp-2 | pQY[Aib]DLFY[Aib]HRa | 0.50 (± 0.61) | 8.32 (± 6.40) |
| 2070[Φ4]wp-4 | pQE[Aib]G[Aib]FW[Aib]NRa | 9.50 (± 6.82) | 18.28 (± 4.37) |
Data are means ± SE. AG, Agonistic activity. ANT, Antagonistic activity. Aib, α-aminoisobutyric acid.