Table 2. Hemodynamic parameters preischemically and during postischemic-reperfusion.
| n | Baseline | Reperfusion | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 2 min | 5 min | 10 min | 20 min | 30 min | 60 min | 120 min | ||||
| LVDP (mmHg) | ||||||||||
| 6 Weeks | non-DM control | 11 | 137 ± 3 | 5 ± 1 | 6 ± 1 | 7 ± 1 | 32 ± 5 | 59 ± 3 | 60 ± 2 | 48 ± 2 |
| non-DM IPC | 8 | 132 ± 4 | 11 ± 3 | 27 ± 6 | 49 ± 8 | 83 ± 6 | 79 ± 5 | 70 ± 5 | 57 ± 5 | |
| T2DM control | 10 | 155 ± 6 | 7 ± 2 | 7 ± 2 | 7 ± 2 | 12 ± 4 | 26 ± 6 | 33 ± 3 | 25 ± 3 | |
| T2DM IPC | 8 | 156 ± 7 | 7 ± 2 | 9 ± 2 | 10 ± 2 | 37 ± 4 | 50 ± 4 | 48 ± 2 | 37 ± 2 | |
| 12 Weeks | non-DM control | 10 | 160 ± 4 | 5 ± 1 | 27 ± 3 | 20 ± 2 | 46 ± 6 | 61 ± 7 | 66 ± 6 | 55 ± 4 |
| non-DM IPC | 9 | 151 ± 7 | 13 ± 2 | 34 ± 5 | 39 ± 5 | 52 ± 6 | 64 ± 4 | 66 ± 4 | 51 ± 3 | |
| T2DM control | 11 | 167 ± 6 | 9 ± 2 | 23 ± 3 | 28 ± 5 | 42 ± 6 | 61 ± 7 | 68 ± 3 | 54 ± 5 | |
| T2DM IPC | 8 | 174 ± 7 | 7 ± 1 | 21 ± 5 | 24 ± 3 | 55 ± 6 | 74 ± 10 | 73 ± 4 | 70 ± 7 | |
| 24 Weeks | non-DM control | 10 | 132 ± 8 | 5 ± 1 | 15 ± 3 | 12 ± 2 | 21 ± 8 | 30 ± 8 | 47 ± 4 | 40 ± 3 |
| non-DM IPC | 9 | 162 ± 4 | 13 ± 2 | 20 ± 5 | 12 ± 3 | 22 ± 6 | 13 ± 2 | 54 ± 4 | 53 ± 4 | |
| T2DM control | 9 | 157 ± 7 | 11 ± 2 | 13 ± 3 | 16 ± 2 | 16 ± 4 | 22 ± 4 | 32 ± 6 | 22 ± 4 | |
| T2DM IPC | 8 | 146 ± 1 | 9 ± 3 | 25 ± 7 | 40 ± 7 | 58 ± 8 | 68 ± 8 | 55 ± 8 | 56 ± 5 | |
| RPP (0.01xmmHgxmin-1) | ||||||||||
| 6 Weeks | non-DM control | 11 | 373 ± 10 | 9 ± 1 | 12 ± 2 | 16 ± 3 | 71 ± 15 | 153 ± 12 | 166 ± 10 | 126 ± 7 |
| non-DM IPC | 8 | 298 ± 27 | 29 ± 10 | 81 ± 19 | 136 ± 21 | 213 ± 17 | 211 ± 22 | 194 ± 17 | 158 ± 17 | |
| T2DM control | 10 | 333 ± 29 | 14 ± 4 | 13 ± 3 | 11 ± 2 | 21 ± 7 | 53 ± 12 | 76 ± 6 | 54 ± 9 | |
| T2DM IPC | 8 | 347 ± 23 | 17 ± 5 | 23 ± 6 | 25 ± 5 | 92 ± 10 | 119 ± 12 | 126 ± 10 | 106 ± 5 | |
| 12 Weeks | non-DM control | 10 | 473 ± 63 | 12 ± 2 | 55 ± 8 | 45 ± 7 | 107 ± 12 | 147 ± 16 | 160 ± 13 | 123 ± 11 |
| non-DM IPC | 9 | 308 ± 28 | 31 ± 5 | 79 ± 14 | 87 ± 16 | 115 ± 13 | 140 ± 12 | 174 ± 18 | 113 ± 13 | |
| T2DM control | 11 | 272 ± 23 | 20 ± 3 | 55 ± 12 | 54 ± 13 | 66 ± 9 | 93 ± 13 | 115 ± 10 | 94 ± 12 | |
| T2DM IPC | 9 | 203 ± 14 | 15 ± 2 | 39 ± 10 | 47 ± 6 | 74 ± 10 | 129 ± 19 | 151 ± 17 | 84 ± 12 | |
| 24 Weeks | non-DM control | 10 | 246 ± 18 | 11 ± 1 | 39 ± 9 | 32 ± 5 | 34 ± 11 | 59 ± 17 | 79 ± 10 | 67 ± 10 |
| non-DM IPC | 9 | 273 ± 27 | 34 ± 6 | 56 ± 13 | 35 ± 13 | 59 ± 16 | 34 ± 7 | 149 ± 15 | 124 ± 20 | |
| T2DM control | 9 | 231 ± 25 | 22 ± 3 | 16 ± 4 | 16 ± 4 | 15 ± 4 | 22 ± 5 | 32 ± 7 | 34 ± 7 | |
| T2DM IPC | 8 | 184 ± 25 | 16 ± 4 | 31 ± 7 | 51 ± 13 | 67 ± 14 | 82 ± 17 | 96 ± 23 | 123 ± 14 | |
| HR (bpm) | ||||||||||
| 6 Weeks | non-DM control | 11 | 273 ± 4 | 198 ± 19 | 216 ± 11 | 230 ± 10 | 213 ± 16 | 255 ± 10 | 272 ± 10 | 261 ± 8 |
| non-DM IPC | 8 | 225 ± 19 | 244 ± 10 | 292 ± 13 | 287 ± 13 | 258 ± 15 | 267 ± 21 | 278 ± 16 | 279 ± 12 | |
| T2DM control | 10 | 217 ± 18 | 194 ± 17 | 225 ± 17 | 195 ± 23 | 201 ± 19 | 197 ± 9 | 231 ± 11 | 217 ± 10 | |
| T2DM IPC | 8 | 226 ± 19 | 236 ± 15 | 237 ± 17 | 249 ± 11 | 252 ± 11 | 238 ± 19 | 265 ± 19 | 288 ± 6 | |
| 12 Weeks | non-DM control | 9 | 292 ± 34 | 219 ± 20 | 205 ± 18 | 241 ± 31 | 246 ± 17 | 229 ± 8 | 231 ± 4 | 224 ± 7 |
| non-DM IPC | 9 | 209 ± 20 | 230 ± 12 | 230 ± 27 | 235 ± 27 | 230 ± 22 | 221 ± 18 | 264 ± 21 | 229 ± 13 | |
| T2DM control | 11 | 166 ± 16 | 234 ± 16 | 236 ± 32 | 209 ± 26 | 170 ± 21 | 154 ± 12 | 170 ± 11 | 182 ± 25 | |
| T2DM IPC | 8 | 123 ± 12 | 237 ± 14 | 231 ± 41 | 234 ± 35 | 147 ± 9 | 206 ± 30 | 219 ± 20 | 128 ± 28 | |
| 24 weeks | non-DM control | 10 | 216 ± 13 | 244 ± 11 | 263 ± 16 | 268 ± 19 | 229 ± 31 | 222 ± 17 | 195 ± 29 | 189 ± 25 |
| non-DM IPC | 9 | 169 ± 16 | 270 ± 9 | 285 ± 22 | 269 ± 18 | 258 ± 34 | 237 ± 17 | 289 ± 7 | 291 ± 18 | |
| T2DM control | 9 | 150 ± 17 | 224 ± 18 | 137 ± 22 | 109 ± 17 | 138 ± 27 | 121 ± 25 | 128 ± 27 | 177 ± 32 | |
| T2DM IPC | 8 | 129 ± 16 | 205 ± 30 | 158 ± 35 | 119 ± 14 | 114 ± 14 | 117 ± 15 | 190 ± 36 | 232 ± 30 | |
Preischemic hemodynamic variables in 6-, 12-, and 24-week-old non-DM rats (heterozygote (fa/+)) and DM ZDF rats (homozygote (fa/fa)) treated with control or IPC. LVDP: Left ventricular developed pressure, RPP: Rate-pressure-product, HR: Heart rate.
Data are mean ± SEM.