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. 2018 Feb 23;13(2):e0193312. doi: 10.1371/journal.pone.0193312

Fig 7. Potentiation of CAP-evoked currents was dependent on PKC and Src kinase activity.

Fig 7

A, representative current traces of CAP-evoked currents obtained from cultured DRG neurons during whole-cell voltage-clamp recording (holding potential set at -60 mV), in control (CTL) and high glucose (HG) conditions in the presence of LY333531 and PP2. B-D, bar graphs summarize maximal current (Imax) density (B), maximal current charge (Qmax; C), and current rundown calculated as the ratio I15/Imax (D). Bars show treatment conditions examined: vehicle (DMSO 1μl/ml, CTL and HG n = 10), LY333531 (CTL, n = 11; HG, n = 9), and PP2 (CTL, n = 5; HG, n = 5). All data are represented as mean ± SEM. The absolute current density and charge were used in B and C for simplicity. Statistical analysis by two-way ANOVA followed by Sidak's post-hoc test. *, p < 0.05.