Table 1. AZD9977 and eplerenone activities on MR, GR, PR and AR in binding assays.
AZD9977 | eplerenone | |||
---|---|---|---|---|
pKi | n | pKi | n | |
MR | 7.5 ± 0.1 | 22 | 7.0 ± 0.1 | 10 |
GR | 5.4 ± 0.1 | 3 | 4.9 ± 0.1 | 3 |
PR | 4.6 ± 0.4 | 3 | 4.3 ± 0.2 | 3 |
AR | <4.3; <4.3 | 2 | 5.3 ± 0.3 | 3 |
Binding constants (pKi) ± standard deviations derived from competition binding experiments. n = number of observations