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Sca4 of various Rickettsia shares significant similarity with vinculin-binding-site (VBS) sequences in mammalian talin-1 or Shigella invasion protein IpaA. Gray: aa residues identical to IpaA2 or talin-1; blue: aa residues similar to IpaA2 or talin-1. Abbreviations: Rcon—R. conorii, Rafr—R. africae, Rpar—R. parkeri, Rric—R. rickettsii, Rasi—R. asiatica, Rhel—R. helvetica, Shs—Shigella sonnei, Hs—Homo sapiens.
