Subjects all ate identical diets and were studied using 15 urine collections during fasting (Fast), from breakfast to lunch (B to L), lunch to supper (L to S), supper to home (S to H), and overnight (ON). CaP SS (lower right panel) of ICSFs exceeded normal controls in the last three periods of the day, and normal controls never achieved an average SS >1 (horizontal dashed line). The main cause of the high CaP SS was urine calcium molarity (upper left panel), which itself arose from hypercalciuria without an accompanying increase of urine volume (lower middle panel). Urine pH values did not differ significantly (lower left panel). Urine CaOx SS of ICSFs exceeded that of normal controls (upper right panel), mainly because of higher calcium molarity; urine oxalate molarity did not differ (upper middle panel). Adapted from reference 46.