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. 2018 Jan 29;10(2):244–255. doi: 10.1080/19420862.2017.1417718

Figure 1.

Figure 1.

In vitro score range for assay controls. Assay negative control mAbs (mAb-01 and mAb-02) and positive control mAbs (mAb-03 and mAb-04) were tested in multiple replicates in the A) DNA binding assay (•), insulin binding assay (□), and AC-SINS assay (∆); B) hFcRn SPR assay (•); and C) immobilized hFcRn affinity column chromatography assay measuring relative retention time (rRT; •) and peak width (PW; □). Assay positive control mAb-05 (AC-SINS only) represents a distinct class of mAbs having high AC-SINS and low DNA and insulin scores. Error bars represent standard deviation.