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. 2018 Jan 29;10(2):244–255. doi: 10.1080/19420862.2017.1417718

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Figure 5. — Retrospective comparison of in vitro parameters and categories to human CL with triage assessment. Data from the set of study mAbs are rank-ordered by descending projected human CL from Tg32 mouse data. In vitro assay data and CL are scored as below threshold (green) or above threshold (red). Triage category: proposed decisions for each molecule based on the combined in vitro assay data are as follows: advance mAb candidate (green; accept mAbs scoring below threshold in 3/3 assay categories); characterize further (yellow; mAbs scoring above threshold in 1/3 or 2/3 assay categories); or do not advance mAb candidate (red; mAbs scoring above threshold in 3/3 assay categories). Key: Assay negative control (mAb-01) and positive controls (mAb-03 and -04) denoted in mAb listing. n/a indicates data not generated.