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. 2017 Dec 14;10(2):304–314. doi: 10.1080/19420862.2017.1409320

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© 2018 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Comparison of i.v. dosed BBB targeting hIgG1TM-IL-1RA fusions in reversal of mechanical hyperalgesia in the Seltzer model of neuropathic pain. Compares the effect of i.v. dosed BBB-IgG and BBBt0626-IL-1RA fusion antibodies on reversal of PNL induced mechanical hyperalgesia by following the ratio of pressure applied to ipsilateral and contralateral hind paws. Sham + Control 40 mg/kg (•), Op + control 40 mg/kg (♦), Op + PBS 10 mg/kg (▾), Op + BBB 40 mg/kg (▪) and Op + BBBt0626 40 mg/kg (▴). Sciatic nerve ligation surgery occurred at base (day 0) and IgG-IL-1RA fusion was administered 13 days post-surgery. Ipsilateral/contralateral ratio followed for a further 4 days. N = 10 per group. Data analyzed using 2-way ANOVA with time and treatment as dependent factors. Subsequent statistical significance obtained using Bonferroni's Post-Hoc test. **p < 0.01 to PNL/NIP-228/Kin control.