Fig. 1.

Diagrammatic representation of full-length RAGE and sRAGE. Full-length RAGE consists of intracellular tail, transmembrane domain, and extracellular domain, comprising of C ₁ , C ₂ , and V domain. V domain binds with AGE. sRAGE is comprised of cRAGE and esRAGE. Both cRAGE and esRAGE lack transmembrane domain and intracellular tail. AGE, advance glycation end-product; RAGE, cell bound receptor for AGE; sRAGE, soluble receptor for AGE; cRAGE, cleaved RAGE; esRAGE, endogenous secretory RAGE; C, constant; V, variable.