Table 1. Expression of Tight Junction, Adherens Junction, Desmosome, and Mesenchymal genes in transforming growth factor-β1 (TGF-β1) exposed immortalized human esophageal epithelial (EPC2-hTERT cells).
Data are expressed as mean fold change versus unstimulated controls ± SEM.
| Name | Fold Change ± SEM TGF-β1 (10 ng/ml) | Significance |
|---|---|---|
| Tight Junction | ||
| Claudin-1 | 1.27 ± 0.13 | n.s. |
| Claudin-4 | 0.63 ± 0.12 | n.s. |
| Claudin-7 | 0.45 ± 0.02 | p<0.01 |
| Occludin | 0.91 ± 0.14 | n.s. |
| Zonula Occluden-1 | 0.79 ± 0.16 | n.s. |
| Adherens Junction | ||
| E-Cadherin | 1.04 ± 0.01 | n.s. |
| Desmosome | ||
| Desmoglein-1 | 1.09 ± 0.30 | n.s. |
| Desmoglein-2 | 1.42 ± 0.17 | n.s. |
| Desmoglein-3 | 1.14 ± 0.33 | n.s. |
| Mesenchymal | ||
| Connective Tissue Growth Factor | 0.88 ± 0.33 | n.s. |
| Smooth Muscle α Actin | 1.16 ± 0.23 | n.s. |
| N-Cadherin | 49.69 ± 11.12 | p<0.05 |