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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Curr Opin Neurobiol. 2017 Dec 23;48:122–130. doi: 10.1016/j.conb.2017.12.003

Figure 1.

Figure 1

Representation of excitatory and inhibitory neuron types in the prefrontal cortex (highlighted in blue, left). Excitatory pyramidal neurons (Pyr) receive perisomatic inhibition from parvalbumin-positive interneurons (PV+) and dendritic inhibition from somatostatin-positive interneurons (SST+). SST+ neurons also provide dendritic inhibition onto PV+ neurons. Vasoactive intestinal peptide–positive neurons (VIP+), a subpopulation of 5-hydroxytryptamine-3a receptor (5HT3aR)-expressing interneurons, inhibit PV+ and SST+ inhibitory neurons, resulting in disinhibition of Pyr neurons.